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Another Study Confirms the Effectiveness of both Flax Oil and Lignans on Reducing Human Breast Cancer Tumors.

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The National Institute of Health (NIH) published the results of a comparative study on the effects of flax lignans, flax oil and the two combined on the growth of established human breast cancers. The result is published below in science-ese, but the layman version is as follows. All three combinations were successful in reducing the tumor growth, but the lignans alone had the greatest effect. Bottom line, flax oil alone is good, but lignans are better. To maximize all the benefits of this superfood, use both!
Comparative Study
 

The effect of secoisolariciresinol diglucoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways

Jasdeep Kaur Saggar 1Jianmin ChenPaul CoreyLilian U Thompson

Affiliations 
    • PMID: 20432175
 DOI: 10.1080/01635580903532440

Abstract

Flaxseed (FS), an oilseed containing high amounts of the phytoestrogen lignan, secoisolariciresinol diglucoside (SDG), and n-3 fatty acid, alpha-linolenic acid-rich oil (FO), has been shown to inhibit the growth of established human breast tumors (MCF-7) in ovariectomized (OVX) athymic mice. However, the major FS component responsible for this effect and the mechanism(s) of its action are unclear. Hence, this study determined, in a 2 x 2 factorial design, the effect of SDG and FO, alone or in combination, on the growth of established human estrogen receptor positive (ER+) breast tumors and the potential mechanism(s) of its action. OVX mice with established ER+ human breast tumors (MCF-7) were treated for 8 wk with basal diet (BD, control) or BD supplemented with SDG (1 g/kg), FO (38.5 g/kg), or SDG + FO. All treatments reduced the tumor growth, but SDG had the greatest effect primarily through reducing tumor cell proliferation rather than increasing apoptosis. SDG had a main effect in the reduction of PS2, BCL2, and IGF-1R mRNA expression, whereas FO had a main effect only in PAKT reduction. SDG alone also lowered the ERalpha, ERbeta, EGFR, BCL2 mRNA, and PMAPK protein, indicating that its effect involves the modulation of the ER- and growth factor receptor-mediated signaling pathways.

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