The Crucial Nature of CoQ10

March 04, 2021

The Crucial Nature of CoQ10

 

Coenzyme Q10 (CoQ10) is a vitamin-like substance found in virtually all cells of
the human body, including the heart, liver, and skeletal muscles, and in most
plant and animal cells.
 As an antioxidant, CoQ10 protects proteins, LDL (“bad”) cholesterol, and
mitochondrial DNA from oxidative damage.*
 As a participant in the production of cellular energy, CoQ10 helps ensure the
body’s biggest energy consumers — the heart and the brain — are well fed.*
Thanks to these two crucial functions, CoQ10 helps maintain blood pressure already
within normal limits,1 supports the integrity of the heart muscle,2 increases circulation
to the heart,3 improves exercise capacity,4, 5 and supports a normal heart rhythm.*6
Additionally, it may protect against mild memory problems associated with aging.*7, 8
Of course, none of these benefits can be realized if CoQ10 isn’t absorbed — and
research indicates that the body takes up only a small fraction of traditional
powder-based (crystalline) CoQ10.
The CoQ10 Absorption Dilemma
CoQ10 is highly lipophilic (fat-loving) and in its powdered crystalline form is practically
insoluble in water. This makes the absorption of typical CoQ10 supplements:
 Poor: Less than 1% of orally administered CoQ10 permeates the aqueous environment
of the gastro-intestinal tract into the blood.9
 Highly variable: Some individuals absorb considerably less CoQ10 than others.
 Strongly dependent on stomach contents: Foods rich in fat enhance absorption.
Making matters worse, CoQ10 is a large molecule, contributing to its poor absorption.
Plus, when CoQ10 is produced commercially, crystals are formed that melt when they
reach 118°F or 48°C. Upon cooling, CoQ10 recrystallizes, which frequently results in
even larger crystals — and further lowers CoQ10 bioavailability.
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat,
cure or prevent any disease.
2 Soft Gel Technologies, Inc.
Illustration by N.R. Fuller, Sayo-Art
The Suspension Solution: CoQsol®
CoQsol® from Soft Gel Technologies is a patented,
oil-based formulation of CoQ10 in the ubiquinone form
with clinically proven enhanced absorption. How is this
enhanced absorption achieved?
The answer is simple, and you may have learned it in high
school chemistry: Like dissolves like. Because CoQ10 is lipophilic,
the scientists who developed CoQsol encapsulated CoQ10 in an
oil-based formulation to give it partial solubility, while adding
specific antioxidants to stop recrystallization, thus enhancing its absorption.
CoQsol®: Ingredients
Ubiquinone CoQ10 Provides Multiple Health Benefits
CoQ10 functions as a carrier to transfer electrons across the
membrane of the mitochondria — the energy-producing
“factories” within cells — to drive production of adenosine
triphosphate (ATP), or cellular energy.* Heart muscles have
the greatest concentration of mitochondria — 5,000 per
cell — which is one reason why CoQ10 is so important for
cardiovascular function.*
In its reduced form, ubiquinol, CoQ10 acts as an antioxidant
to protect proteins, LDL (“bad”) cholesterol, and
mitochondrial DNA from oxidative damage.* Research has
shown that CoQ10 supplementation exerts a sparing effect
on vitamin E in healthy subjects, helping to maintain its
antioxidant state. It also reduces levels of lipid peroxidation
— and thus supports cardiovascular health.*
Several factors can deplete CoQ10 levels in the body:
 Aging
 Certain medications, such as statin drugs
 Certain disease states
Rice Bran Oil Allows for Lymphatic Absorption*
CoQ10 crystalline powder does not dissolve completely
in the lipid portion of the small intestine. The solution?
Add fat. Not just any fat, however. Rice bran oil naturally
contains gamma oryzanol, a plant sterol with lipid-like
solubility. As a result, it enables the CoQ10 in CoQsol® to
be absorbed through the lymphatic system as a fat.*
Tocopherols and Carotenoids Prevent Recrystalization
A form of vitamin E, tocopherols enhance the biological
function of CoQ10, which in turn helps maintain
the antioxidant state of vitamin E.* Carotenoids are
antioxidant phytonutrients that give orange vegetables
like carrots and sweet potatoes their characteristic
hue. Both tocopherols and carotenoids interfere with
the recrystallization of CoQ10, allowing for better
absorption.*
* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
 
CoQSol® Has Enhanced Bioavailability Compared
with CoQ10 Crystalline Powder
In a randomized placebo-controlled study, 36 volunteers aged 22 to 58, with normal CoQ10 levels and no previous
history of CoQ10 supplementation, were divided into three groups: CoQ10 crystalline powder (in a two-piece hard shell
capsule), CoQsol® (as a hermetically sealed softgel), or a placebo.
In the first phase of the study, researchers determined steady state blood levels of CoQ10 by measuring fasting
blood levels one week before supplementation began and again on days 0, 15, 30, and 45 (15 days after the end of
supplementation). In the second phase of the study, peak absorption rate was determined by measuring fasting
blood levels of CoQ10 before and five hours after taking a single 30-mg dose of the nutrient.
Phase I: Steady State Basal Blood CoQ10 Levels Over 30 Days of Supplementation
 2.2 x Higher Steady State Levels: After 30 days, blood CoQ10
levels of the CoQ10 crystalline powder group rose by 76%
(0.85 μg/ml to 1.5 μg/ml) whereas those of the CoQSol®
group rose by 165% (0.85 μg/ml to 2.26 μg/ml) — meaning
CoQSol® boosts blood levels of CoQ10 2.2 times better than
CoQ10 crystalline powder.
 2 Weeks to Near-Peak Levels: CoQ10 levels approached peak
plasma levels after two weeks and then rose more slowly for
another two weeks.
 On-Going Supplementation Needed: Once supplementation
ceased, plasma CoQ10 levels dropped back to baseline levels
after two weeks, indicating the need for on-going supplementation.
4 Soft Gel Technologies, Inc.
Phase II: Peak Absorption Rate 5 Hours After Ingestion
 2.5x Higher Peak Absorption: CoQ10 levels of the CoQ10
crystalline powder group increased 0.19 μg/ml (average
absorption of 3.4 μg/ml), whereas those of the CoQsol®
group increased 0.48 μg/ml (average absorption of
9.3 μg/ml) — meaning a single dose of CoQsol® increased
blood CoQ10 levels 2.5 times more than CoQ10 crystalline powder.
 2.6x Higher Total CoQ10 Absorption: After five hours,
the CoQ10 crystalline powder group had absorbed just
693 μg/ml CoQ10, while the CoQsol® group had
absorbed an impressive 1,813 μg/ml — 2.6 times more.
Better Absorption Means Increased Energy
When the subjects’ CoQ10 levels rose, the practical results of
supplementation were clear:
 The placebo group experienced no change in energy.
 Only 30% in the CoQ10 crystalline powder group felt such an increase.
 Yet a full 83% of subjects in the CoQsol® group noticed an increase in energy.*
That’s not surprising, because CoQ10 feeds the mitochondria — tiny energy
producers within cells.*
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to
diagnose, treat, cure or prevent any disease.
www.soft-gel.com 5
Who Should Take CoQsol®?
CoQsol® is the perfect nutritional supplement for anyone who:
 Is Over 40
With age, people produce less CoQ10 and become less efficient
at converting ubiquinone (the form of CoQ10 featured in CoQsol®)
to ubiquinol (the form used by the body to neutralize free radicals
and create energy in the form of ATP). However, those who are
young and healthy can easily make this conversion. Therefore,
taking ubiquinol may be an unnecessary expense for this population.
 Needs a boost in energy*
One of the primary benefits of CoQ10 is to increase energy production.*
In a randomized placebo-controlled study, 83% of subjects taking CoQsol®
noticed an increase in energy, compared to just 30% of those taking CoQ10 crystalline powder.*
 Is Taking Statins
Certain medications, such as statin drugs, and certain disease states can deplete CoQ10 levels in the body.
Supplementation can restore CoQ10 stores to normal levels (at least 0.8 μm/ml).
 Wishes to strengthen cardiovascular or brain health*
Because of its role in energy production, CoQ10 supports the functioning of organs with a high demand for
energy, such as the heart and brain.* The heart muscle in particular is in constant need of a ready supply of
energy to efficiently pump blood throughout the body. In fact, the majority of cardiac tissue is abundant in
mitochondria requiring ample and consistent levels of CoQ10 for proper functioning.*
 Is looking for a non-dietary way to increase CoQ10 levels
Most people don’t eat enough foods containing CoQ10 — such as fatty fish, organ meats, and whole grains —
to raise blood levels of the nutrient. In fact, the average dietary intake of CoQ10 is only 3-5 mg a day, much
lower than what’s needed to have any effect on CoQ10 concentrations.10 CoQsol® has been clinically proven to
achieve significantly higher plasma concentrations of CoQ10 compared with CoQ10 crystalline powder.
CoQsol® Delivery Systems
CoQsol® is an off-the-shelf formulation available in five different potencies—
10 mg, 30 mg, 60 mg, 100 mg and 200 mg softgels. As an oil-based suspension of CoQ10
clinically demonstrated to provide superior absorption, CoQsol® is the ubiquinone
CoQ10 of choice for discriminating manufacturers.
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose,
treat, cure or prevent any disease.
6 Soft Gel Technologies, Inc.
www.soft-gel.com 7
References
1 Yamagami T, et al. Bioenergetics in clinical medicine. Studies on coenzyme Q10 and essential hypertension. Res Commun Chem Pathol Pharmacol.
1975; 11:273.
2 EBSCO Publishing. “Cardiomyopathy.” Consumerlab.com. Accessed June 9, 2009. http://www.consumerlab.com/tnp.asp?chunkiid=21484#ref1
3 EBSCO Publishing. “Cardiomyopathy.” Consumerlab.com. Accessed June 9, 2009. http://www.consumerlab.com/tnp.asp?chunkiid=21484#ref1
4 Kamikawa T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol. 1985 Aug 1;56(4):247-51.
5 Wilson, M.R., et al. Coenzyme Q10 therapy and exercise duration in stable angina. In: Folkers, K., Littami, G.P., Yamogami, T. (eds),
Biomedical and Clinical Aspects of Coenzyme Q10, vol. 6, Amsterdam. Elsevier;1991:339-348.
6 Singh RB, et al. Randomized double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction.
Cardiovasc Drugs Ther. 1998;12:347-353.
7 Muller T, et al. Coenzyme Q(10) supplementation provides mild symptomatic benefit in patients with Parkinson’s disease.
Neurosci Lett. 2003;341:201-204.
8 Young AJ, et al. Coenzyme Q10: A Promising Treatment for Alzheimer’s Disease? Abstr AcademyHealth Meet. 2004; 21: abstract no. 1715.
9 Not all CoQ10 products are created equal. Insiders Health. Feb. 20, 2009. http://www.insidershealth.com/article_print/not_all_coq10_
products_are_equal/2621
10 Weber C, Bysted A, Hłlmer G. The coenzyme Q10 content of the average Danish diet. Int J Vitam Nutr Res.
1997;67(2):123-9.
CoQsol® is a multi-ingredient soft gelatin CoQ10 formulation, which delivers
powerful antioxidants vital to human health. This unique, synergistic blend
of CoQ10, natural vitamin E, Pro-vitamin A from natural beta-carotene, and
rice bran oil is clinically proven to provide superior absorption.* It may
also replenish CoQ10 levels depleted by statin drugs.* Known as the
“biochemical spark,” CoQ10 is a widely–studied nutrient that assists
in normal heart function and promotes efficient cellular energy
production.*
* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

Why CoQsol®?
 Several factors can deplete CoQ10. Research shows that aging, certain medications such as statin drugs, and certain
disease states can deplete CoQ10 levels in the body. Therefore, for many people, supplementation is indicated to
replenish CoQ10 stores to normal levels.
 CoQ10 in powder (crystalline) form is difficult to absorb. Because of its highly lipophilic (fat-loving) structure, CoQ10
is practically insoluble in water, making its absorption poor, highly variable, and strongly dependent on stomach
contents. Plus, the CoQ10 molecule is large in size, contributing to its poor absorption, and when heated and
re-cooled, even larger crystals are created.
 Suspending CoQ10 in rice bran oil improves its bioavailabilty. Rice bran oil contains gamma oryzanol, a plant sterol
with lipid-like solubility. As a result, it enables the CoQ10 to be absorbed through the lymphatic system as a fat.*
 Adding tocopherols and carotenoids prevents recrystallization. Both tocopherols and carotenoids interfere with
the recrystallization of CoQ10, allowing for better absorption.*
 CoQsol® has clinically proven enhanced bioavailability. A randomized placebo-controlled human clinical trial
found that compared to CoQ10 crystalline powder, CoQSol® achieved:
 2.2x higher steady state blood levels of CoQ10 after 30 days (60 mg/per day)
 2.5 higher peak absorption rate 5 hours after ingestion of a single dose (30 mg)
 2.6x higher total CoQ10 absorbed 5 hours after ingestion of a single dose (30 mg)
 CoQsol® Increases Energy.* A full 83% of subjects in the human clinical trial who were taking CoQsol® noticed an
increase in their energy levels, as opposed to 30% taking powdered CoQ10 and no change for those taking placebo.*
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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